Cosmelan ®  Depigmentation treatment

Skin ageing caused by systematic sun exposure, facial blemishes due to excessive pigmentation and, in general, imperfections caused by melanin, are more and more common problems today…
“Dark blemishes”, especially on hands and face, are one of the greatest aesthetic concerns of modern men and women…
It will only be possible to remove the anti-aesthetic skin blemishes and recover the smoothness of the skin, bringing back its luminosity, with a treatment that has a direct effect on the intimate formation process of the pigment (melanin).


COSMELAN - CHARACTERISTICS

Cosmelan® Depigmentation treatment guarantees the improvement of the anti-aesthetic skin blemishes with a very high safety margin.  Cosmelan® Depigmentation treatment’s principal action is the elimination of melanin patches on the face (melasma and chloasma).  Cosmelan® Depigmentation treatment involves a very versatile, dynamic process which is easily adapted to the needs of each individual patient. 

Cosmelan® Depigmentation treatment action mechanism is based on the inhibition of tyrosinase, a basic enzyme in the melanin formation process. Several of the substances present in the Cosmelan® formula act by blocking this enzyme, or even by inverting the metabolic process of the transformation chain.  Melanogenesis comprises the following stages:
TYROSINE proceeds to DOPA by means of TYROSINASE.

DOPA proceeds to DOPAQUINONE by means of TYROSINASE.

DOPAQUINONE proceeds to PHAEOMELANINE and EUMELANIN by means of oxidation and cyclization.

ADVANTAGES
The Cosmelan® Depigmentation treatment offers a series of major
advantages and benefits compared with other types of
depigmentation products found in the market:
•        Very effective in all types of melasma
•        Rapid and easy depigmenting action
•        Compatible with ALL skin types (Fitzpatrick I – VI)
•        Light peeling effect
•        Rejuvenates the skin
•        Treatment can be used all year round
•        Beneficial for acne patients
•        Does not contain TCA
•        High safety margin

RESULTS
In 99% of the cases, the disappearance of the blemishes improves by 95%...
ONE WEEK after starting the Cosmelan® Depigmentation treatment, a noticeable significant improvement of the skin is observed! The reduction of the treated blemish is detected and the appearance of new luminous and rejuvenated skin is present.  At the end of the Cosmelan® Depigmentation treatment, the blemishes start to disappear altogether, so that, although the
patient may be able to “locate” the place where the spot was, the truth is that the pigmentation will have disappeared and nobody will be able to see it just by looking at it.

Cosmelan works by blocking the process that causes hyperpigmentation. It works for:

•        Melasma
•        Brown Spots
•        Blotchy Skin
•        Hyperpigmentation
•        Post-inflammatory hyperpigmentation
•        Prevention of hyperpigmentation post-laser and post-peel

ACTIVE INGREDIENTS - Cosmelan® Pack
Degreasing Solution
Aqua, Acetone

Cosmelan® 1 - Cream (10g)
Azelaic Acid, Kojic Acid, Phytic Acid, Ascorbic Acid, Arbutine,
Titanium Dioxide

Cosmelan® 2 – Maintenance Cream (30g)
Titanium Dioxide, Kojic Acid, Phytic Acid, Ascorbic Acid

mesoestetic® Hydra Vital Factor K Cream (50ml)
Hydro nutritional cream for face and neck. Hydroviton, VItamin K,
Vitamin E, Amniotic fluid, Glycerine, Silicone oil.

PRELIMINARY INFORMATION FOR THE PATIENT
Important: it must be known if the patient has undergone any previous treatments, especially with glycolic acid. If confirmed, any treatment, especially Glycolic Acid, must be eliminated at least, one week prior to using Cosmelan® Depigmentation treatment.   The Cosmelan® Depigmentation treatment initiated at the medical office must be continued at home, on a daily basis, according to the guidelines indicated.  The treatment must not be interrupted under any circumstances, during the whole time prescribed.  It is completely forbidden to combine the Cosmelan® Depigmentation treatment with other depigmentation treatments, as the appearance of undesired effects cannot be guaranteed.
Treatment control visits are recommended. 8 days after beginning of treatment, 15 days after, and a follow up visit every month thereafter.

EVOLUTION AFTER COSMELAN 1
First and second day

During the first two days of the treatment, the skin may turn red.  If the skin is very sensitive, the patient may experience an itching feeling.  Slight burning and tightening of the skin is also absolutely normal,  especially during the first 24 to 48 hours after starting the treatment.  To relieve these problems, it is advisable to apply the mesoestetic®
Hydra-vital factor K whenever necessary. 

Reddening of the Skin

The reddening that occurs on the face after applying the mesoestetic® Cosmelan 1 treatment is similar to the effects of day-long exposure to the sun in the snow without protection. (Intense reddening in photo type I and II and practically non existent in photo type IV and V)

Flaking
Flaking may occur on all skin types (and more intensely in photo types I and II) between the second and third day. In this case it is advisable to apply the mesoestetic® Hydra-vital factor K cream, repeating this every two hours on the day when the flaking is most intense.

Third and fourth day
After the third or fourth day, the skin appears healthy and luminous and the marks begin to fade.

HOME TREATMENT - Cosmelan® 2 Maintenance Cream
The second phase of the Cosmelan® treatment consist of a home maintenance cream Cosmelan 2® with the intention of securing the depigmentation by association of agents such as Kojic Acid, Phytic Acid, and Vitamin C. We have added a physical agent to block the sun and guarantee that the UV rays do not keep on aggravating unwanted cutaneuos hyper pigmentation.  This Cosmelan 2® cream should be applied 2 times per day during the first two weeks, and once a day from the third week on, and at least, during a whole year to secure the obtained results guaranteeing an optimum depigmentation response.